Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Hlavní nádraží | Brussels South/Midi Train Station | Cheapest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | Fastest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags |
Last refresh of the prices: Yesterday at 23:38 CEST.
Compare 2 ways to travel from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 17 hours 55 minutes and with fares starting at just CLP 42,048, it presents an excellent value for a comfortable ride.
37bus per day
17h 55mAverage duration
442 milesDistance
18kgCO₂ emissions
Where are the popular train stations and stops in Prague and Brussels?
Prague
- A
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia - B
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia - C
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - E
Holešovice
Praha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia - F
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
18/08
CLP 269,768
19/08
No data
Today
CLP 403,792
21/08
No data
22/08
No data
23/08
CLP 180,939
24/08
No data
25/08
CLP 134,610
The cheapest trip from Prague to Brussels was searched and found on 25 Aug 2026 with a price of CLP 134,610To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels as early as possible.
You can expect to pay from CLP 134,610 to CLP 764,365 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 134,610, which is on 2026-08-25.
